VDR is a gene that encodes for a vitamin D receptor protein. This protein regulates calcium absorption and bone development. A variant of the gene (rs2228570, FokI polymorphism) is associated with reduced bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the reciprocal and temporal pattern of off- and on- occupancy of the VDRE by the two components, and is influenced by chromosomal positions and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes possess a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) could be an archive of information and documents relevant to business, legal transactions, or procedures. Viewing, downloading, or printing is restricted. It is accessed via a central server as well as an extranet connection which is an geschaeftsmarketingstrategie Internet connection with restricted access, to provide controlled log-on for set times at which users can access the documents and data.
VDRs are typically used by investment banks and companies involved in mergers or acquisitions. They need an efficient and secure platform to share information with investors or buyers in a clear and transparent manner, and the process of due diligence may require large amounts of data. Life science companies also use VDRs for everything from clinical trial data to HIPAA compliance documentation.